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Lymphoid cells from unprimed high responder (C57BL/10) and low responder mice (B10.Br, B10.A, CBA) to (T,G)-A-L and high responder (B10, B10.A) and non-responder (B10.G, DBA/I) mice to GAT can be induced to form antigen specific T-helper cells in vitro under identical culture conditions. The helper cells induced from high and low or non-responder mice appear to be identical in efficiency, antigen concentration requirement for induction and induction kinetics.

Type

Journal article

Journal

Immunology

Publication Date

03/1977

Volume

32

Pages

291 - 299

Keywords

Antibody-Producing Cells, B-Lymphocytes, T-Lymphocytes, Cells, Cultured, Animals, Mice, Inbred Strains, Mice, Peptides, Antigens, Epitopes, Dose-Response Relationship, Immunologic, Histocompatibility, Time Factors