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The latest updates on our research and how it is improving people’s lives.

Ethnic representation within the Tendon Human Cell Atlas to be improved with Chan Zuckerberg Initiative funding

Funding Main

NDORMS researchers have been awarded funding from the Chan Zuckerberg Initiative to ensure that tendon samples from understudied ethnic groups are included in the Tendon Human Cell Atlas.

Knee OA guidance for clinicians simplified and streamlined

Knee Main

Researchers review the similarities and differences between OARSI and ESCEO 2019 guidelines for the management of knee OA and provide a narrative to help steer health-care providers through the complexities of non-surgical management of the disease.

Understanding the physics of the immune response necessitates new technology

Kennedy Main

Professor Marco Fritzsche has joined the Kennedy Institute as the Principal Investigator of the Biophysical Immunology Laboratory (BPI), as part of a joint appointment with the Rosalind Franklin Institute. His lab is leading the development of a lattice light sheet microscope that will significantly advance the study of live cells.

CD2 corolla calls T cells to arms

Kennedy Main

A team from the University of Oxford has visualised how key cells of the immune system lock onto cancerous or infected cells to destroy them. The work was led by the Mike Dustin’s group at the Kennedy Institute of Rheumatology and experts in colorectal and ovarian cancers from across Oxford and computational biologists at the University of Birmingham.

Likely culprits causing blood vessel lesions in vasculitis identified

Kennedy Main

NDORMS researchers identify a subset of immune cells that could be a new therapeutic target to treat inflamed blood vessels in Giant Cell Arteritis (GCA) and other forms of inflammatory vascular disease.

Review of proposed FDA regulation reveals the extent of financial ties to industry

Botnar Main

A review of public comments on a proposed FDA regulatory framework, for modifications to artificial intelligence and machine learning-based software as a medical device, has found that 63% came from parties with financial ties to industry, and that the majority, 86% did not cite any scientific evidence.

Professor Stride announced as Honorary Fellow of IET

Awards Botnar Main

Institution of Engineering and Technology announces 16 Honorary Fellows to mark its 150th year. Professor Stride was awarded the Fellowship in recognition of her contribution to biomedical engineering and research into treatment of major diseases.

Carpal tunnel decompression surgery found to be a safe option for patients

Botnar Main

One of the leading causes of workplace absence, carpal tunnel syndrome, can be treated successfully with decompression surgery without serious complications according to research from NDORMS.

Hospitalised COVID-19 patients shown to be younger and healthier than flu patients

Main

Patients hospitalised with COVID-19 were more likely male, younger and, in both the US and Spain, had fewer comorbidities and lower medication use than hospitalized influenza patients according to a recent study published recently by the Observational Health Data Sciences and Informatics (OHDSI) community.

Research review reveals potential to improve colon cancer treatments

Kennedy Main

Researchers at the Kennedy Institute review the growing body of literature on the role of the microbiome in colorectal cancer

Oxford researchers start new trial on the use of anti-TNF to treat Covid-19 in care homes

Main Trials

Researchers at the University of Oxford are starting a new study to explore the effectiveness of the anti-tumour necrosis factor (anti-TNF) drug adalimumab as a treatment for patients with COVID-19 in the community, especially care homes. The AVID-CC trial, which will be conducted by Oxford Clinical Trials Research Unit (OCTRU), will enrol up to 750 patients from community care settings throughout the UK.

Professor Chris Lavy awarded prestigious honorary fellowship by British Orthopaedic Association

Awards Main

Professor of Orthopaedic and Tropical Surgery and Consultant Orthopaedic and Spine Surgeon Chris Lavy has been awarded a prestigious honorary fellowship by the British Orthopaedic Association (BOA).

Key discovery in Psoriatic Arthritis points way for developing targeted treatments

Arthritis Main

A new study has revealed psoriatic arthritis may be activated by the same trigger in different patients. Researchers from the University of Oxford and the Wellcome Sanger Institute identified high levels of a specific receptor in immune cells from psoriatic arthritis patients, giving the strongest evidence yet of a single cause for the disease.

Research success leads to expansion

Botnar Main

A new wing is being built to expand the Botnar Research Centre and advance its research into musculoskeletal science and bioengineering technologies.

Patients set to benefit from new guidelines on Artificial Intelligence health solutions

Main

Patients could benefit from a faster and more effective introduction of artificial intelligence (AI) innovations to diagnose and treat disease – thanks to the first international standards for reporting of clinical trials for AI.

Workload linked with an increased risk of knee osteoarthritis

Arthritis Main

Men and women working in heavy manual occupations are twice as likely to suffer from knee osteoarthritis (OA), the most common joint disorder, compared to those in sedentary occupations according to a new study published in the prestigious journal Seminars in Arthritis and Rheumatism.

Cancer care during COVID-19: lessons from The Oxford Bone Tumour and Soft Tissue Sarcoma service

Bone oncology Main

Sarcoma cancer in Oxford was reorganised during the pandemic. Two studies reveal their success and serve as a guide to other units facing the similar challenge of supporting patients.

Largest global study on hydroxychloroquine safety finds increased cardiovascular risk with azithromycin

Main

The combination of hydroxychloroquine (HCQ) and azithromycin (AZM) has been linked to significant cardiovascular risks including mortality, in the largest safety study ever performed on both HCQ and HCQ+AZM.

Patient’s fundraising takes him to the top of Scafell Pike

Main

Hip replacement patient Nick Birch scales his second mountain to raise funds for University research

IL-22 pathway linked to poor prognosis in colon cancer

Kennedy Main Oncology

Research shows how IL-22 interacts with KRAS mutant tumours to promote excessive growth in colorectal cancer

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