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The latest updates on our research and how it is improving people’s lives.

New atlas of stromal cells maps out potential for treating human fibrosis

Kennedy Main

Research at the Kennedy Institute reveals sub-populations of stromal cells with distinct functions in human fibrotic disease. These findings could inform development of more specific therapies with fewer off-target effects.

Understanding of inflammatory bowel disease moves a step closer

Kennedy Main

Published in Science Immunology, researchers at the Kennedy Institute have identified the role of IRF5 in controlling intestinal inflammation.

Dr. Michael Dustin joins Strategic Research Collaboration with Cue Biopharma

Kennedy Main

The research will test innovative technology that harnesses the body’s intrinsic immune system to transform the treatment of cancer and autoimmune diseases.

New weapon identified in arsenal against disease

Kennedy Main

Researchers in the Dustin Group reveal supramolecular attack particles are autonomous killing entities released from cytotoxic T lymphocytes

Managing clinical trials during the pandemic

Main Trials

Duncan Richards, Climax Professor of Clinical Therapeutics and Director of the Oxford Clinical Trials Research Unit (OCTRU) is interviewed about clinical trials and the challenges of running them in a pandemic.

The NDORMS response to COVID-19

Botnar Kennedy Main

A number of members of the department are actively helping with the response to the COVID pandemic. Playing a key role in research, literature reviews, clinical trials and engineering projects, all have a shared commitment to collaborate globally to tackle the pandemic.

Professor Fiona Powrie elected to the National Academy of Sciences in the USA

Awards Kennedy Main

Fiona was recognised for her outstanding contributions to immunology, and her election brings the number of current National Academy of Sciences members from the Kennedy Institute to three.

Live imaging shows surprising passage of T cells in the spleen

Kennedy Main

Research from Tal Arnon’s group at the Kennedy Institute reveals a network of perivascular pathways that guide T cells into the spleen.

Childhood obesity increases the risk of fracture new study finds

Main

Overweight or obese pre-school children have a higher risk of bone fractures during childhood than those of normal weight according to a new study published in the Journal of Bone & Mineral Research.

COVID-19 prognosis and prediction models for medical decision-making are flawed, say researchers

Main

The modelling and approach to tackle the hard medical decisions associated with the spread of the COVID-19 virus may be based on weak and overly-optimistic evidence from studies that are biased and unreliable, suggests research published by The BMJ today.

Professor Alan Silman receives Nuffield Foundation grant for research into joint replacement surgery

Funding Main

The three year funding will provide evidence on how musculoskeletal conditions progress and their effect on people’s well-being and life chances.

Oxford-led research describes the safety profile and potential harms of hydroxychloroquine and azithromycin

Botnar Main Statistics and epidemiology

Over 300 international researchers from the Observational Health Data Sciences and Informatics (OHDSI) community studied data from almost 1 million patients. They declared hydroxychloroquine safe for short-term use, but urge caution in using it in combination with azithromycin.

NDORMS team joins the race to develop a prototype for rapidly deployable ventilator

Botnar Main

An interdisciplinary team of engineers and medics is addressing ways to increase the UK's capacity for ventilator manufacture.

NDORMS researchers leading a virtual study-a-thon to tackle COVID-19

Botnar Main

The Observational Health Data Sciences and Informatics (OHDSI) international community will host a COVID-19 virtual study-a-thon this week (March 26-29) to inform healthcare decision-making in response to the current global pandemic.

Coronavirus information - what we are doing at NDORMS to support our staff and students and the community

Botnar Kennedy Main

NDORMS announces the closure of the Kennedy and Botnar Institutes and outlines other plans and activities for the department during the pandemic.

The rationale and ethics of placebo controls in surgical trials

Main Publication

A new Review, published in the Lancet, analyses the use of placebo controls in surgery and offers a practical checklist for researchers designing trials.

Researchers identify markers in joint fluid that could be the key to cartilage repair

Arthritis Kennedy Knee Main

Molecular changes in the joint fluid during surgical joint distraction reveal markers that may drive cartilage repair in osteoarthritis.

CRUK success for NDORMS researchers

Funding Kennedy Main

Investigators based at the Kennedy Institute of Rheumatology, NDORMS have recently received CRUK awards to increase understanding of a variety of cancers and immunotherapy.

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