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News

The latest updates on our research and how it is improving people’s lives.

Surgeons using medical instruments

New research programme to strengthen the evaluation of implants in the NHS

A major new NIHR funded programme grant aims to make medical implants safer and better value for money in the NHS. The project will develop a robust framework to assess the long-term risks, benefits and costs of implants.

Ed Burn, Antonella Delmestri and Paula Dhiman

Associate Professor title awarded to NDORMS researchers

The University of Oxford has awarded the title of Associate Professor to Ed Burn, Antonella Delmestri and Paula Dhiman.

James Fullerton appointed as John Climax Professor of Clinical Therapeutics

Professor Fullerton will take a leading role in clinical pharmacology and experimental medicine research in Oxford to help bridge the gap between discoveries in the laboratory and the development of new drug treatments.

A young girl dressed with a cape and with a white bandage on her left arm

Large UK trial shows bone healing ‘superpower’ in children

Most children with a severely broken wrist can be treated without surgery, according to a major NIHR-funded UK trial led by researchers at the University of Oxford. The findings suggest that a non-surgical, cast-first approach delivers similar long-term recovery while reducing the risks associated with surgery and costs.

Close up of woman holding painful elbow with red inflammation area, representing arthritis.

£3M study led by patient voices targets pain in inflammatory arthritis

Researchers across the UK are banding together to tackle one of the largest unmet clinical needs in inflammatory arthritis, pain reduction, in a new £3m research programme funded by Arthritis UK.

Liver organoid visualised by live multi-colour fluorescence confocal imaging, acquired at the ZEISS 980 in the Oxford-ZEISS Centre of Excellence. The image shows the nucleus of different cell types present in the tissue in blue, the cholangiocytes in orange, and collagen fibers in red. The new SPI-LLSM method now allows the quantitative measurement of the reaction diffusion dynamics of small molecules across such organoids.

Oxford–ZEISS Centre to advance live-cell imaging for drug discovery

The pioneering technology will be able to precisely quantify drug behaviour at the cellular level for the development of novel therapeutics.

Kennedy Institute of Rheumatology secures five-year major funding from the Kennedy Trust for Rheumatology Research

The Kennedy Institute of Rheumatology (KIR) at the University of Oxford has secured a major five-year funding commitment of £28 million from the Kennedy Trust for Rheumatology Research (KTRR), extending its long-standing strategic partnership to 2031.

Jonathan Rees

Professor Jonathan Rees reappointed as NIHR Senior Investigator

The NIHR Senior Investigator award recognises the most prominent and prestigious researchers of applied health and social care.

Narain Karedla

New microscopy methods to reveal how electrostatics shape biological processes

Dr Narain Karedla has received a 5-year European Research Commission (ERC) grant for the project ‘Metal-Induced Energy Transfer based Electrometry and Nanometry’ (MIETEN) to be carried out at the Botnar Institute and the Rosalind Franklin Institute. The project aims to develop new optical microscopy methods for probing the role of electrostatics in biological processes.

James Fullerton and Loren Kell

New industrial partnership to advance human immunology research and accelerate therapeutic development

A new collaboration between the Translational Pharmacology Group at NDORMS and global biopharmaceutical company UCB aims to promote understanding of human adaptive immunity and catalyse the development of new treatments for patients with immune-mediated conditions.

Clinician using medical data

New study shows observational analyses can complement randomised clinical trials findings for the study of HPV vaccine effectiveness

Led by researchers at NDORMS as part of the Data Analysis and Real World Interrogation Network (DARWIN EU®) initiative, a new European study has shown that carefully designed observational studies can produce robust and reliable vaccine effectiveness estimates. These results highlight that high-quality real-world evidence can play a key role in complementing the findings from randomised clinical trials.

Doctors reviewing patient data

Fair and Safe Medical AI: why local expertise matters

A Global Grand Challenges case study reveals the potential of large language models (LLMs) to close health gaps in the South Asia, but only when they’re adapted and fine-tuned using local data and expertise.

Cytotoxic T cell

Anchoring a key immune molecule boosts T cell responses

Researchers at the Kennedy Institute of Rheumatology have found that physically resisting the formation of an immunological synapse actually promotes a stronger immune response. The findings could help explain how immune responses become weakened in cancer and chronic infection and inform the design of more effective vaccines.

Doctor treating patient

Oxford joins new West Africa consortium to accelerate climate and health solutions

Researchers from the University of Oxford have joined African universities and regional experts who are working with Wellcome to establish new science and policy consortiums that will address the escalating public health crisis driven by climate change - saving lives and livelihoods.

Woman carer helping a man with a walking stick

'Hidden' costs of social care after a hip fracture exceed £1.25 billion a year in the UK

Social care for hip fracture costs the NHS over £1.25 billion, equating to £15K per patient every year according to a new NDORMS study.

Confusion and uncertainty

Drugs identified that could help prevent delirium after surgery

A new study has found that several commonly used drugs could significantly reduce the risk of delirium in older people following surgery.

AI medical records

Public trust in health data sharing for AI is conditional

Public support for sharing health data for artificial intelligence (AI) research depends on clear public benefit, strong safeguards, and meaningful consent, according to a new NDORMS study based on in-depth focus groups with members of the UK public.

Broken ankle in a leg cast

A step forward for ankle fracture management

In an editorial piece published in The BMJ, NDORMS Professors David Keene and Matthew Costa commend a new clinical trial that advances the understanding of ankle fracture treatment.

Woman with arthritis in her hand

Kennedy scientists join world-leading researchers in ‘pivotal’ study to help arthritis patients to live drug free

The prospect of long-lasting drug-free remission for children and adults living with inflammatory arthritis is a step closer to becoming a reality, thanks to a new collaboration.

DNA damage

Rapamycin helps protect immune cells against DNA damage

New research carried out by Dr Loren Kell at NDORMS, has demonstrated for the first time that rapamycin can reduce DNA damage in immune cells, a hallmark of ageing.

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