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Research

Our mission is to undertake the highest quality research in musculoskeletal and inflammatory conditions to deliver new treatments, which improve people's lives. We have world-class facilities, with purpose-built laboratories and state-of-the-art equipment. Our multidisciplinary research is thriving, supported by large infrastructure grants from the National Institute for Health Research and the Kennedy Trust for Rheumatology Research. In addition, a number of charities make significant contributions, most notably Arthritis Research UK and the Wellcome Trust, as well as collaborations with Industry. The Departments research spans the following themes.

Alsaleh Group | Aging in the musculoskeletal system
Alsaleh Group | Aging in the musculoskeletal system
Arden Group | Epidemiology of Musculoskeletal Diseases
Arden Group | Epidemiology of Musculoskeletal Diseases
The main focus of the lab is to understand how humoral immune responses are regulated within the spleen.
Arnon Group | Lymphocyte Trafficking and Adaptive Immunity
Our research goal is to elucidate mechanisms that control the initiation of inflammatory responses in innate immune cells.
Bezbradica Mirkovic Group | Macrophage Biology in Inflammation
Biopatch
Biopatch
Our main research goal is to understand the molecular mechanisms causing inflammation, particularly in Ankylosing Spondylitis and other forms of inflammatory arthritis including Psoriatic Arthritis, and to translate this understanding into new patient therapy.
Bowness Group | Immunology of Ankylosing Spondylitis
We aim to uncover the stromal basis of chronic inflammation and related tissue pathology to target fibroblasts across a range of immune-mediated inflammatory diseases.
Buckley Group | Stromal Cell Biology
Established in 2013, the Centre for Osteoarthritis Pathogenesis Versus Arthritis aims to develop new treatments for this disabling condition, improving healthcare and transforming people's lives.
Centre for OA Pathogenesis
Our group is working on a range of projects to develop, evaluate and introduce modern therapy technologies in the National Health Service. Our work focuses on people who have life changing musculoskeletal injury and / or substantial chronic health conditions.
Centre for Rehabilitation Research in Oxford
Centre for Sport, Exercise and Osteoarthritis
Centre for Sport, Exercise and Osteoarthritis
Centre for Statistics in Medicine
Centre for Statistics in Medicine
Chen group | Immunogenomics in Autoimmunity and Cancer
Chen group | Immunogenomics in Autoimmunity and Cancer
Clarke Group | Metabolism and Immunity
Clarke Group | Metabolism and Immunity
We take an interdisciplinary approach from single-molecule imaging to multi-scale computational modelling and experimental validation to identify and develop therapeutic strategies for immune-mediated inflammatory disease.
Coles Group | Stromal and Systems Immunology
Work in the Cribbs lab focuses on developing novel single-cell technology and computational analysis frameworks that empower new modes of treatment for disease.
Cribbs Group | Computational and Systems Biology
The Dakin Group undertakes translational research focusing on identifying the cellular and molecular basis of inflammatory fibrotic soft tissue joint diseases, with research programmes on tendinopathy and arthrofibrosis. Understanding the cellular and molecular basis of these diseases will inform new therapeutic approaches targeting tissue resident stromal cells of the joint, to promote resolution of inflammatory fibrotic disease.
Dakin Group | Soft Tissue Joint Disease
Dustin, L Group | Viral Infection and Immunity
Dustin, L Group | Viral Infection and Immunity
Dustin, M Group | Immunological Synapse
Dustin, M Group | Immunological Synapse
We aim to identify the mechanisms contributing to bone disease caused by cancer and develop new treatments for these conditions.
Edwards Group | Bone Oncology
Our work focuses on Ageing and Longevity mechanisms, identifying and characterising factors which control lifespan to better understand and treat age-related disorders.
Edwards Group | Musculoskeletal Ageing
The EQUATOR Network is an international initiative set up to help researchers and journals to publish well-reported, reliable, and usable research papers. The UK EQUATOR Centre, based in NDORMS, is the head office and flagship centre of the EQUATOR Network.
EQUATOR Centre UK
Feldmann Group | Unravelling the Role of Cytokines in Disease
Feldmann Group | Unravelling the Role of Cytokines in Disease
Primary research goal is the identification and characterisation of the mechanisms of mechanobiology controlling the immune response in health and disease. Our objectives involve the application and development of novel ultrasensitive live-cell microscopy techniques with the right spatiotemporal sensitivity as demanded by the biology. Long-term goal of our research is the translation of our expertise and methodologies in mechanobiology to mechanomedicine in diagnostics and treatment of patients.
Fritzsche Group | Biophysical Immunology
Our group aims to understand the biology of common hand conditions, as well as other related surgical disorders. We use this knowledge to develop and test new treatments for these disabling conditions. We also investigate the epidemiology of hand and upper limb conditions, including hand trauma, to guide best practice.
Furniss Group | Genetics and Epidemiology of Common Hand Conditions
We are interested in understanding how CD8 T cell responses are organised in space and time to achieve the correct balance between tolerance and immunity.
Gérard Group | Spatiotemporal Dynamics of T Cell Responses
Our research focuses on hip osteoarthritis, from identifying its causes to developing new surgery techniques for the condition.
Glyn-Jones Group | Hip Research Group
We are a collaborative group of academic researchers, therapists, physicians, and surgeons, who work together to understand the epidemiology, pathogenesis, and clinical impact of common hand conditions. Our ultimate aim is to improve the care of patients with hand and wrist problems.
Hand Research Group
Our research aims to improve people's health and wellbeing by making the most efficient use of health and social care resources. To achieve this, we use real-world data and mathematical models to evaluate the costs and consequences of applying different interventions over a period of time, often the entire lifetime of patients.
Health Economics & Outcomes Research
Hulley group research is directed towards understanding skeletal soft tissue disease pathology and devising effective regenerative strategies.
Hulley Group | Tendon and Ligament Physiology
We aim to understand the mechanisms behind uncontrolled cell migration - which promotes progression of certain conditions - to develop new treatments to prevent this progression.
Itoh Group | Cell Migration
Plastic surgery is a small surgical specialty covering hand surgery, trauma, congenital defects, burns and cancer. Plastic surgeons work with all other surgical specialties to undertake complex reconstructions and save lives.
Jain Group | Outcome Studies and Translational Research in Musculoskeletal Surgery
We are interested in studying all aspects of rare disease of the musculoskeletal system. At present we are prioritising disorders including skeletal dysplasia / metabolic bone diseases, vasculitides, arthritides and connective tissue diseases, rare reactions to bone therapies and myeloma.
Javaid Group | Rare Bone Diseases and Osteoporosis Epidemiology
Applying multi-omic and computational genomic approaches to understand the molecular basis of host-microbiome interactions
Johnson Group | Microbiome and Multi-omics
We seek to identify multi-gene signatures of shared immune variation to better understand disease genetics and health outcomes.
Jostins Group | Statistical Genetics of Immune Variation
There is a need for information on what makes for a good model of health service delivery, in terms of clinical and cost-effectiveness, to ensure everyone gets the best care available.
Judge Group | Health Service Delivery
We are deeply involved in research, teaching and training to strengthen surgical care and training capacity in Africa.
Lavy Group | Global Surgery
Lim Group | Molecular Imaging Group
Lim Group | Molecular Imaging Group
We develop statistical methods and computational software to better understand the genetic contribution to immune-mediated traits.
Luo Group | Statistical genomics and computational immunology
Over the last ten years we have focused our research on developing better approaches to the diagnosis of vasculitis.
Luqmani Group | Vasculitis and GCA
We are responsible for providing the Institute with solutions to problems associated with the wide diversity of data generated and used by our scientists.
Marsden Group | Research Informatics
Our group investigates how the extracellular matrix - the component of tissue that lies immediately outside and between cells - contributes to inflammation.
Midwood Group | Matrix Immunology
Molecular Genetics of Carpal Tunnel Syndrome
Molecular Genetics of Carpal Tunnel Syndrome
Monaco Group | Cardiovascular Inflammation
Monaco Group | Cardiovascular Inflammation
We develop biomaterials and dynamic bioreactor systems for soft tissue repair applications.
Mouthuy Group | Soft Tissue Engineering
Nanchahal Group | Treating Fibrosis and Improving Tissue Regeneration
Nanchahal Group | Treating Fibrosis and Improving Tissue Regeneration
The research in our group focuses on target identification and validation in a spectrum of human diseases including benign and malignant soft tissue tumours or hematological malignancies affecting the skeleton such as multiple myeloma, and inflammatory conditions including endometriosis, cardiovascular disease, or autoimmune diseases.
Oppermann Group | Epigenetic Mechanisms in Musculoskeletal Disease
Oxford Clinical Trials Research Unit
Oxford Clinical Trials Research Unit
Orthopaedic engineering is a highly active and fascinating area of research, which has the potential to directly benefit patient healthcare.
Oxford Orthopaedic Engineering Centre
Oxford Orthopaedic Simulation and Education Centre (OOSEC)
Oxford Orthopaedic Simulation and Education Centre (OOSEC)
Oxford Psoriatic Arthritis Centre (Ox-PACE)
Oxford Psoriatic Arthritis Centre (Ox-PACE)
Our research focuses on the clinical and cost effectiveness of orthopaedic surgery.
Oxford Trauma
Planned Operations for Children (0-16 years old) with Orthopaedic Conditions affecting the Lower Limb from hips to toes
Paediatric Lower Limb Surgery Group
Our research covers interests in the fields of cancer research and stem cell biology. We focus on the molecular mechanisms of pancreatic cancer formation, particularly the function of TGFβ/Activin/Nodal-Smad2/3 signalling pathway in the formation and maintenance of cancer stem cells in pancreatic ductal adenocarcinomas.
Pauklin Group | TGFß signalling in cancer stem cells
Observational Research - Pharmaco-epidemiology - Methods Research
Pharmaco- and Device epidemiology
Planetary Health Informatics (PHI)
Planetary Health Informatics (PHI)
The Powrie lab employs basic and translational science to study host-microbe crosstalk in health and disease, focussing on inflammatory bowel disease (IBD), colorectal cancer (CRC) and inflammatory arthritis. Research spans observational and functional analysis of a broad range of cell types including bacteria, fibroblasts, T cells and neutrophils.
Powrie Group | Mucosal Immunology
We focus on research that can directly improve the outcome for patients who undergo surgery for degenerative osteoarthritis of the knee.
Price Group | Knee Research Group
Professor Rees has research themes aimed at improving the treatments and care of orthopaedic patients by IMPROVING TREATMENT DELIVERY TO PATIENTS THROUGH TECHNOLOGY INNOVATIONS, TRIALS AND EPIDEMIOLOGY.
Rees Group | Surgical Technology, Surgical Learning and Delivery of Orthopaedic Treatments
ROAM | Research at Oxford on Analysis of Motion
ROAM | Research at Oxford on Analysis of Motion
The foundation of this group’s work is understanding and improving how we measure outcomes in clinical studies. We aim to deploy our outputs and use our knowledge and experience in high quality clinical studies and applications that measure what really matters.
Rodrigues Group | Measurement Science and clinical studies
Work in the Sansom lab focuses on identifying the cellular and molecular causes of immune mediated inflammatory disease (IMID) using systems-level approaches.
Sansom Group | Computational and Single Cell Genomics Group
Simon Group | Autophagy in the Immune System
Simon Group | Autophagy in the Immune System
Snelling Group | Soft Tissue Repair
Snelling Group | Soft Tissue Repair
Stride Group | Biomaterials & Biomechanics
Stride Group | Biomaterials & Biomechanics
We aim to be a centre of excellence for the design and management of surgical trials, focussing on answering important health questions in the UK and worldwide.
Surgical Interventions Trials Unit
We aim to develop new treatments for musculoskeletal conditions, through innovative laboratory work and clinical trials.
Taylor Group | Inflammation Translational Research
The Potential Role of Pro-resolving Mediators for the Treatment of Tendon Inflammation
The Potential Role of Pro-resolving Mediators for the Treatment of Tendon Inflammation
Cerebral palsy is the most common cause of childhood disability. The Theologis Group will run the first ever set of trials into cerebral palsy, to address the issues that matter the most to patients and provide evidence-based solutions.
Theologis Group | Paediatric Orthopaedics
Work in the Udalova is focused on understanding how the inflammatory response is controlled on the molecular level.
Udalova Group | Genomics of Inflammation
Upper Limb Epidemiology Group | Orthopaedic and Plastic Surgery
Upper Limb Epidemiology Group | Orthopaedic and Plastic Surgery
Our research focuses on all aspects of osteoarthritis, from understanding its causes to developing new treatments for the condition to improve people's quality of life.
Vincent Group | Molecular Pathogenesis of Osteoarthritis
Cells use unique spaces to organise the messaging that modifies their behaviour and respond to their environment. Our research looks at how one such space - the primary cilium - affects the way cells respond to external cues including mechanical force and inflammatory cytokines.
Wann Group | Primary Cilia in Musculoskeletal Health and Disease
Our group tests findings from the laboratory in human clinical studies, and runs experimental medicine studies and clinical trials relevant to osteoarthritis within the Arthritis Research UK Centre for Osteoarthritis Pathogenesis.
Watt Group | Translational Research in Osteoarthritis
Our work is geared towards the development of new treatments and healthcare strategies for rheumatoid arthritis and other autoimmune diseases.
Williams Group | Targeting Disease Pathways in Rheumatoid Arthritis
Ankylosing Spondylitis is a common form of inflammatory arthritis predominantly affecting the spine. It is believed that more than 100 different genes are involved in the condition.
Wordsworth Group | Genetics of Ankylosing Spondylitis