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Kennedy Institute researchers Alex Clarke and Thomas Riffelmacher have been awarded prestigious Wellcome Trust Fellowships to further develop their research in autoimmune diseases.

Biophysical determinants of cell fate decisions in skin inflammatory diseases

Neo-antigen challenge to uncover the formation and persistence of CD4 T resident memory cells in humans

Clinical and cost effectiveness of AI-enabled vertebral fracture identification Fracture Liaison Services (FLS)

Resident memory B cell responses in the lung; immunity against pulmonary pathogens

Vaccine LEGACY – Applying a systems based approach to accelerate vaccine development

Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy

Harnessing human genomic, transcriptomic and proteomic data to identify novel therapeutic targets

How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?

New pattern-recognition receptor signalling modalities in inflammation

Microbiome metabolites as immune checkpoints

Granulopoiesis: chromatin topology and associated functions

How does ageing influence intrinsic cartilage repair in osteoarthritis?

Resident memory B cell responses in the lung; immunity against pulmonary pathogens

How inflammatory macrophages instruct innate effector responses in the tumour microenvironment?

Engineering Resolution – mRNA targeting of chronic inflammatory disease

Investigating cross-tissue and cross-disease immune mechanisms using single-cell/spatial multiomics & machine learning/AI-powered language learning tools

Mechanical force matters in T-cell activation

Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy

Harnessing human genomic, transcriptomic and proteomic data to identify novel therapeutic targets

How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?

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Meet the researchers

  • Alex Clarke
    Alex Clarke

    Principal Investigator and Honorary Consultant Rheumatologist, Nuffield Orthopaedic Centre

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Arthritis Therapy Acceleration Programme

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