Resting functional connectivity reveals residual functional activity in Alzheimer's disease.
Zamboni G., Wilcock G., Douaud G., Drazich E., McCulloch E., Filippini N., Tracey I., Brooks J., Smith S., Mackay C.
Functional MRI (fMRI) has great potential for unravelling mechanisms of functional decline in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI), but task-fMRI studies have produced conflicting results, partly due to failure to account for underlying morphological changes, and to variations in ability to perform the tasks. Resting-fMRI is promising because it does not require a task. We aimed to improve the understanding of how resting-fMRI relates to brain function.