Triggering of the high-affinity IgE receptor in an aggregation-independent manner
Felce J., Sezgin E., Wane M., Dustin ML., Eggeling C., Davis SJ.
The high-affinity IgE receptor, FcεR1, is responsible for the sensitization of mast cells and basophils to IgE-targeted anti- gens. The current model of FcεR1 triggering rests on the principle of aggregation-driven phosphorylation, yet several recent observations have indicated that this is incomplete. Here we re-examine the minimal requirements for FcεR1 triggering and observe that it is induced without receptor aggregation by surface-associated antigen in a size-dependent manner.