Knee osteoarthritis and the risk of premature mortality in the community: an international individual patient level meta-analysis in 9889 subjects
Leyland KM., Gates LS., Sanchez-Santos MT., Prieto Alhambra D., Judge A., Collins G., Cleveland R., Felson D., Jordon JM., Callahan LF., Nevitt M., Saberi Hosnijeh F., Van Meurs JB., Jones G., Newton J., Batt M., Altman D., Cooper C., Arden N.
The rising prevalence of osteoarthritis (OA) is recognised has having an impact on the increased need for medical consultations due to pain and functional limitations; however, the effect of OA on mortality is less understood. A recent systematic review has shown that there is currently mixed evidence on the relationship between lower limb OA and all-cause mortality, largely due to heterogeneity in definitions of OA, confounders, and inclusion criteria. The aim of this research was to combine individual patient data (IPD) from major international population-based cohorts using harmonised OA data, and to assess whether subjects with knee OA have an increased association with premature mortality.