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RIDD
The RIDD trial aims to test whether the progression of Dupuytren’s disease can be halted or slowed by treatment with anti-TNF injection. Currently, Dupuytren’s disease is left to progress until the finger deformity is severe enough to warrant a surgical procedure in hospital. If successful, anti-TNF treatment would prevent loss of hand function and the need for surgery, and would allow patients to be treated conveniently and quickly.
CSAW
NDORMS coordinated this multicentre randomised controlled trial (RCT) at 32 hospitals in the UK with 51 surgeons via the Surgical Intervention Trials Unit (SITU) and in collaboration with co-chief investigators Professors David Beard and Andrew Carr. The trial was funded by Arthritis Research UK (Ref.19707)
CORKA
The CORKA study was developed in response to a commissioned call by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme for research into a functional home based rehabilitation programme for patients who may be at risk of poor outcome after knee arthroplasty.
Powrie Group | Mucosal Immunology
The Powrie lab employs basic and translational science to study host-microbe crosstalk in health and disease, focussing on inflammatory bowel disease (IBD), colorectal cancer (CRC) and inflammatory arthritis. Research spans observational and functional analysis of a broad range of cell types including bacteria, fibroblasts, T cells and neutrophils.
Sansom Group | Computational and Single Cell Genomics Group
Work in the Sansom lab focuses on identifying the cellular and molecular causes of immune mediated inflammatory disease (IMID) using systems-level approaches.
Williams Group | Targeting Disease Pathways in Rheumatoid Arthritis
Our work is geared towards the development of new treatments and healthcare strategies for rheumatoid arthritis and other autoimmune diseases.
Arnon Group | Lymphocyte Trafficking and Adaptive Immunity
The main focus of the lab is to understand how humoral immune responses are regulated within the spleen.
Itoh Group | Cell Migration
We aim to understand the mechanisms behind uncontrolled cell migration - which promotes progression of certain conditions - to develop new treatments to prevent this progression.
Udalova Group | Genomics of Inflammation
Work in the Udalova Lab is focused on understanding how the inflammatory response is controlled on the molecular level.
Vincent Group | Molecular Pathogenesis of Osteoarthritis
Our research focuses on all aspects of osteoarthritis, from understanding its causes to developing new treatments for the condition to improve people's quality of life.
Jain Group | Outcome Studies and Translational Research in Musculoskeletal Surgery
Plastic surgery is a small surgical specialty covering hand surgery, trauma, congenital defects, burns and cancer. Plastic surgeons work with all other surgical specialties to undertake complex reconstructions and save lives.
Midwood Group | Matrix Immunology
Our group investigates how the extracellular matrix - the component of tissue that lies immediately outside and between cells - contributes to inflammation.