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Dr Laura Coates has been awarded £1.8M from the National Institute for Health Research (NIHR) to explore the potential for precision medicine in the choice of biologics to reduce inflammation and pain in psoriatic arthritis.

Psoriatic arthritis research

Research finds that surgery for Dupuytren’s disease is effective, but repeat operations come with higher risks

Hand Main Research

Research by NDORMS Dominic Furniss, Professor of Plastic and Reconstructive Surgery, finds that surgery for the common hand disorder Dupuytren’s disease is safe and effective. However, repeat surgery could carry higher risks of complications such as finger amputation.

Celebrating World Clubfoot Day

Botnar Main Orthopaedics and trauma Research Translational medicine

More than 30,000 children in Africa are born with clubfoot each year. With treatment simply not available where they live, many thousands of these children get no treatment and end up with severe deformities that make it hard and very painful to walk.

Repurposed drug can induce remission of inflammatory arthritis

Inflammation biology Kennedy Main Research

Researchers at the Kennedy Institute demonstrate that the drug decitabine can boost regulatory T cell responses.

Study reveals the three most important aspects of care for hip fractures

Hip Main OCTRU Research Trauma

Older patients with hip fractures recover better if they receive treatment under the supervision of both a surgeon and a specialist in elderly care; are checked to avoid future falls; and are assessed for memory problems.

The role of mAbs (neutralising monoclonal antibodies) in the fight against COVID-19

Main Research

Neutralising mAbs, a form of anti-viral medicine, are being explored as an attractive option to treat symptoms of COVID-19 and in some cases prevent infection. But what are the pros and cons of this type of treatment and what should regulators consider before granting approval?

Small mechanical forces in immune cells measured at unprecedented sensitivity

Kennedy Main Research

Oxford researchers have used advanced microscopy techniques to measure previously unseen forces generated by cells during an immune response; a breakthrough for mechanobiology and future advances in health and disease.

Cognitive–behavioural therapy consistently improves quality of life

Main Rehabilitation and self-management Research

A meta-review of the available research into cognitive behavioural therapy reveals it consistently improves health-related quality of life across different medical conditions and demographic populations.

Oxford to collaborate with Janssen to map the cellular landscape of immune mediated disorders

Main Research

The University of Oxford has entered into a strategic collaboration with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

WHiTE Four trial results published

Hip Main OCTRU Orthopaedics and trauma Research Trauma

The results of the WHiTE Four clinical trial for the treatment of fragility hip fractures have been published in The Bone and Joint Journal.

Understanding the first wave of COVID-19 and implications for tackling the ongoing pandemic: evidence from 5.5 million people from Catalonia, Spain

Botnar Main Research Statistics and epidemiology

Health outcomes during the first wave of COVID-19 in Catalonia, Spain, have been described in detail in a study published by Nature Communications.

Immunology preprint reviews launched in Nature Reviews Immunology

Kennedy Main Research

The Oxford-Mount Sinai (OxMS) Preprint Journal Club has partnered with Nature Reviews Immunology to launch a monthly Preprint Watch column.

Living reviews launched by Oxford and Cardiff in the wake of COVID-19 research

Kennedy Main Research

In a combined effort to help COVID-19 researchers the University of Oxford and Cardiff University have launched a series of “living reviews” in Oxford University Press’s new open access journal “Oxford Open Immunology”.

3D imaging reveals the role of blood vessels in hormone production

Kennedy Main Research

New research from the Kusumbe Group at the Kennedy Institute has shown a direct correlation between age-related decline in capillary and artery numbers and hormone production in the endocrine system.

Could do better: clinical trial reporting fails to live up to the mark

CSM Main OCTRU Research

The statistical analysis and reporting of treatment effects in reports of randomised trials with a binary primary endpoint requires substantial improvement, suggests NDORMS research published in BMC Medicine.

Study reveals how cancer cells use bone marrow fat for growth and survival

Bone oncology Main Research

As society battles with an obesity epidemic, new research from the Edwards group shows how increased body fat contributes to cancer establishment and progression.

Cancer progression may be controlled by targeting tumor-specific extracellular matrix

Kennedy Main Oncology Research

Researchers have uncovered how tumors exploit tenascin-C to deflect the body’s natural defence against them.

New collaboration aims to shape future drug development

Botnar Main Research

The EU-PEARL project will take a systematic approach that enables patient-focused, cross company collaborative platform trials.

Researchers identify link in the treatment of inflammatory bowel disease (IBD)

Kennedy Main Research

A new study published in the Journal of Experimental Medicine reveals how IL-10 and PGE2 work together to prevent inflammatory tissue damage and maintain a healthy gut balance

Study reveals ‘postcode lottery’ for hip and knee replacement physiotherapy

Hip Knee Main Research

Post-operation physiotherapy following hip and knee replacement varies significantly across the UK according to new research by Dr Toby Smith, leading to a ‘postcode lottery’ for patients.

Cancer Research UK Senior Fellowship awarded to John Christianson

Funding Main Research

John Christianson, Associate Professor at NDORMS, has been awarded a £2 million Cancer Research UK Senior Cancer Research Fellowship to explore new treatments for patients with multiple myeloma.

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Meet Laura

  • Laura Coates
    Laura Coates

    NIHR Clinician Scientist and Senior Clinical Research Fellow

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The largest, most extensive global network study on background rates for adverse events of special interest identifies important age, sex and database differences that should inform future safety surveillance efforts.

Professor Keith Willett recognised in Queen’s Birthday Honours

Professor of Orthopaedic Trauma Surgery at NDORMS, Keith Willett becomes a Knight Bachelor for services to the NHS.

Professor Dani Prieto-Alhambra elected to ISPE Board of Directors

Dani Prieto-Alhambra, Professor of Pharmaco- and Device Epidemiology at NDORMS, has been elected as the Academic representative for Europe and Africa on the International Society of Pharmaco-Epidemiology Board of Directors.

New research from the Kennedy Institute of Rheumatology identifies a role for CD200 in limiting atherosclerosis

A new study published in Circulation Research shows that CD200, an inhibitory immune checkpoint, reduces the development of atherosclerosis.

EPSRC funds research to avert an antibiotics apocalypse

Researchers at the Kennedy Institute join a collaboration to find new ‘drug-free’ ways of treating illnesses where current treatments have become ineffective due to antibiotic resistance.

Research finds that surgery for Dupuytren’s disease is effective, but repeat operations come with higher risks

Research by NDORMS Dominic Furniss, Professor of Plastic and Reconstructive Surgery, finds that surgery for the common hand disorder Dupuytren’s disease is safe and effective. However, repeat surgery could carry higher risks of complications such as finger amputation.