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NEOPANC-01 is a window of opportunity study looking to assess gene expression in patients with resectable pancreatic cancer. It aims to evaluate the utility of whole transcriptome RNA sequencing as a potential biomarker for future window-of-opportunity trials that will assess existing and/or new treatments for pancreatic cancer. An understanding of the variability in the transcriptomic signature between biopsies will also inform power calculations for future studies. Lastly, the data generated will be available for use as historical controls for future studies. 2 sets of biopsy samples will be taken throughout the trial. Firstly during an endoscopic ultrasound procedure and then again, up to 6 weeks later, during the patients surgery to remove the cancer. Once all patients have been recruited, the mRNA from the samples will be sequenced and analysed. Further samples will also be taken at the same time points for storage into a biobank and for use in future research. This is a single site study opening at the Churchill Hospital looking to recruit 10 patients over 18 months.
Connects-UK launches to foster scientific collaborations between EU and UK researchers in a post-Brexit era
Kennedy Main Research
10 April 2024
Connects-UK, a new pan-European network dedicated to advancing scientific collaborations between researchers in the European Union (EU) and the United Kingdom (UK), was officially launched at an event in London yesterday. The network, led by a diaspora of EU researchers working in the UK, seeks to bridge the gap created by Brexit and ensure that collaboration, innovative research, funding, and knowledge exchange continue to thrive in the post-Brexit era.
New study reveals how T cells gain and maintain tolerance to gut bacteria
Inflammation biology Kennedy Main Research
4 April 2024
The immune system in the intestine maintains a careful balance, tolerating our long-term resident (commensal) gut bacteria while defending against invading pathogens. Under certain circumstances, dysregulation of our intestinal immune response to commensal and pathogenic microbes can drive inflammatory disease.
New framework guides the use of AI for clinical diagnosis
Botnar Main Research
25 March 2024
NDORMS researchers have conducted a review of the literature on the use of AI in clinical decision-making. Published in the Lancet the study identifies why AI has not yet been taken up more widely, and provides a framework to better inform future adoption and integration of the technology.
Removing bias from healthcare AI tools
Botnar Main Research Statistics and epidemiology
22 February 2024
Rapid advances in Artificial Intelligence (AI) have opened the way for the creation of a huge range of new healthcare tools, but to ensure that these tools do not exacerbate preexisting health inequities, researchers urge the use of more representative data in their development.
Frozen shoulder holds the key to understanding fibrosis resolution
Main Research Shoulder
19 February 2024
NDORMS researchers have identified how cells work to resolve frozen shoulder, opening up potential new targets for treatment and reducing the need for surgery.
New research improves accuracy of molecular quantification in high throughput sequencing
Botnar Main Research
5 February 2024
A team at NDORMS has developed a new approach to significantly improve the accuracy of RNA sequencing. They pinpoint the primary source of inaccurate quantification in both short and long-read RNA sequencing, and have introduced the concept of “majority vote” error correction leading to a substantial improvement in RNA molecular counting.