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Could do better: clinical trial reporting fails to live up to the mark
8 June 2020
The statistical analysis and reporting of treatment effects in reports of randomised trials with a binary primary endpoint requires substantial improvement, suggests NDORMS research published in BMC Medicine.
Study reveals how cancer cells use bone marrow fat for growth and survival
17 January 2020
As society battles with an obesity epidemic, new research from the Edwards group shows how increased body fat contributes to cancer establishment and progression.
Cancer progression may be controlled by targeting tumor-specific extracellular matrix
15 January 2020
Kennedy Main Oncology Research
Researchers have uncovered how tumors exploit tenascin-C to deflect the body’s natural defence against them.
New collaboration aims to shape future drug development
18 December 2019
The EU-PEARL project will take a systematic approach that enables patient-focused, cross company collaborative platform trials.
Researchers identify link in the treatment of inflammatory bowel disease (IBD)
6 December 2019
A new study published in the Journal of Experimental Medicine reveals how IL-10 and PGE2 work together to prevent inflammatory tissue damage and maintain a healthy gut balance
Study reveals ‘postcode lottery’ for hip and knee replacement physiotherapy
5 December 2019
Post-operation physiotherapy following hip and knee replacement varies significantly across the UK according to new research by Dr Toby Smith, leading to a ‘postcode lottery’ for patients.
Cancer Research UK Senior Fellowship awarded to John Christianson
2 December 2019
John Christianson, Associate Professor at NDORMS, has been awarded a £2 million Cancer Research UK Senior Cancer Research Fellowship to explore new treatments for patients with multiple myeloma.
Platelet rich plasma found to be of no benefit in treating torn Achilles tendon
20 November 2019
New research from the University of Oxford has shown that platelet rich plasma (PRP) is not effective in treating acute Achilles tendon ruptures.
Dissecting TNF signalling in inflammatory disease
28 October 2019
Inflammation biology Kennedy Main Research
New research from Dr Richard Williams’ group at the Kennedy Institute suggests a route for the development of more selective – and effective – therapies for immune-mediated inflammatory disease.
Protective mediators can help heal injured tendon cells by attacking inflammation
11 October 2019
Inflammation biology Main Research
Findings reported in The American Journal of Pathology suggest specialized proresolving mediators may become therapeutics that alleviate chronic tendon inflammation
Increased use of partial knee replacement could save the NHS £30 million per year
17 July 2019
Botnar Knee Main Publication Research Trials
New research from a randomised clinical trial published today in The Lancet and funded by the National Institute for Health Research (NIHR) shows that partial knee replacements (PKR) are as good as total knee replacements (TKR), whilst being more cost effective.
Vaccine developed to treat osteoarthritic pain
12 March 2019
Kennedy Main Publication Research
Researchers have developed a vaccine that blocks the effects of the main cause of pain in osteoarthritis (OA) - nerve growth factor (NGF) - in mice.
Genes and height matter for carpal tunnel syndrome
4 March 2019
Botnar Main Publication Research
Researchers from the University of Oxford and Estonia have found further evidence that a person’s genetic make-up and height can influence whether they will develop carpal tunnel syndrome (CTS).
Risks of shoulder replacement surgery higher than previously thought
20 February 2019
Botnar Main Orthopaedics and trauma Publication Research
Need for further surgery particularly high in younger men and serious complications surprisingly common in older people, say researchers.
New drug class could offer a targeted safer treatment alternative for patients with rheumatoid arthritis
15 February 2019
Arthritis Kennedy Main Publication Research
A new treatment targeting tenascin-C could reduce the progression and severity of rheumatoid arthritis (RA) at the very early stages of disease.
Study suggests immune system plays key role in survival after pancreatic cancer surgery
12 February 2019
Kennedy Main Publication Research
Researchers in Oxford have found that an individual’s immune system – and in particular the presence of T-cells amongst tumour cells – may play an important role in survival after surgery to remove pancreatic cancer.
One step closer to targeted therapies for joint inflammation
4 January 2019
Inflammation biology Main Publication Research
New discoveries on how tissue cells, known as stromal cells contribute to chronic joint inflammation could hold the key to innovative targeted treatments for patients with refractory joint disease.
NDORMS part of large European project on health data and evidence network
22 November 2018
Botnar Main Research Statistics and epidemiology
Professor Daniel Prieto-Alhambra of NDORMS will lead a work package on the generation of evidence from European wide observational data as part of a new Innovative Medicines Initiative project, the European Health Data & Evidence Network (EHDEN).
Research for better shared decision-making in knee surgery
24 September 2018
New research by a team at the University of Oxford and the NIHR Oxford Biomedical Research Centre and published today in The Lancet provides robust basis for informed shared decision-making and consent on keyhole knee surgery.
Oxford scientists discover key factor that ‘alerts’ stem cells to accelerate healing of multiple tissues
27 April 2018
Kennedy Main Orthopaedics and trauma Publication Research
Researchers at the Kennedy Institute, University of Oxford have found that a single administration of a molecule accelerated healing of multiple tissues when administered after or even before injury.