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New Research from the Kusumbe group at the Kennedy Institute of Rheumatology identifies vascular attrition, marked by pericyte to fibroblast differentiation, as a primary hallmark of aging and highlights organ-specific vascular changes with age.

A montage of images showing 3D scans of mouse spleens and kidneys — From left to right 1 - Tile scan 3D confocal image showing a mouse spleen with multicolour immunolabeling for endothelial cell and pericyte markers. Blue shows cell nuclei stained with TO-PRO-3. 2 - Tile scan 3D confocal image showing a mouse spleen with multicolour immunolabeling for endothelial cell and pericyte markers. 3 - Tile scan 3D confocal image showing a mouse kidney with multicolour immunolabeling for endothelial cell and pericyte markers. Blue shows cell nuclei stained with TO-PRO-3. 4 - Tile scan 3D confocal image showing a mouse kidney with multicolour immunolabeling for endothelial cell and pericyte markers.

Subharmonics are not an infallible safety metric for cavitation dynamics.

Wu Q. et al, (2026), Int J Hyperthermia, 43

Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature.

Scherlinger M. et al, (2026), J Transl Autoimmun, 12

Comorbidities, medication use, and overall survival in eight cancers: a multinational cohort study of 1.7 million patients across Europe.

López-Sánchez I. et al, (2026), Lancet Reg Health Eur, 63

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis.

Beernaert B. et al, (2026), Sci Adv, 12

Validating Primary and Secondary Healthcare Resource Use and Costs estimates in OMOP-Mapped vs Source CPRD-HES Data in the UK

Pinedo Villanueva R., (2026)

Characteristics, treatment and survival of patients with chondrosarcoma in five European countries: a DARWIN EU® cohort study.

Barchuk A. et al, (2026), Acta Oncol, 65, 193 - 200

Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism

Howard MC. et al, (2026), Proceedings of the National Academy of Sciences, 123

Unveiling the association between low-density lipoprotein cholesterol lowering and fracture risk : real-world evidence from a target trial emulation study.

Wen Z. et al, (2026), Bone Joint Res, 15, 227 - 237

Implementation of OMOP and ConcePTION Common Data Models in CPRD GOLD: Risk of Bleeding and Cardiovascular Outcomes From Anticoagulant Use.

Hunt NB. et al, (2026), Clin Pharmacol Ther

The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice.

Johnstone JC. et al, (2026), PLoS Biol, 24

Checkpoint blockade amplifies pro-regenerative type 2 immunity in tissue repair.

Romero Arocha S. and Clarke A., (2026), Nat Rev Immunol

Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing.

Li X. et al, (2026), Cell Mol Immunol

Surgery versus non-surgical splint treatment for proximal phalanx shaft finger fractures in adults: the POINT Randomised Controlled Trial.

Karantana A. et al, (2026), Health Technol Assess, 1 - 41

Cohort Study on Drug Survival and Tolerability of Adalimumab Biosimilar Transitioning: Pharmaceutical Properties Do Matter.

Peeters ACD. et al, (2026), Clin Pharmacol Ther, 119, 651 - 659

Determinants of six-minute walk test performance in individuals with knee osteoarthritis.

Mylvaganam S. et al, (2026), Osteoarthr Cartil Open, 8

Supervised versus self-managed rehabilitation for patients with an acute first-time or recurrent patellar dislocation: the Physiotherapy Rehabilitation Post Patellar Dislocation (PRePPeD) external pilot randomized controlled trial and embedded qualitative study.

Forde CP. et al, (2026), Bone Joint J, 108-B, 310 - 321

Time to reframe osteoporosis: a position statement to characterize the osteoporosis care gap.

Paskins Z. et al, (2026), JBMR Plus, 10

Outcomes in Early Adulthood for Individuals Born Very Preterm and/or with Very Low Birth Weight: Evidence from Multinational Cohorts.

Pilvar H. et al, (2026), J Pediatr Clin Pract, 19

Severe necrotizing soft tissue infections (SENSEI) study: Protocol for a multi-centered audit.

Yoshimura R. et al, (2026), JPRAS Open, 48, 331 - 336

Quantitative Systems Pharmacology Models of Anti-Amyloid Treatments for Alzheimer's Disease: A Systematic Review.

Herriott L. et al, (2026), CPT Pharmacometrics Syst Pharmacol, 15

Search results

Showing results for

Subharmonics are not an infallible safety metric for cavitation dynamics.

Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature.

Comorbidities, medication use, and overall survival in eight cancers: a multinational cohort study of 1.7 million patients across Europe.

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis.

Validating Primary and Secondary Healthcare Resource Use and Costs estimates in OMOP-Mapped vs Source CPRD-HES Data in the UK

Characteristics, treatment and survival of patients with chondrosarcoma in five European countries: a DARWIN EU® cohort study.

Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism

Unveiling the association between low-density lipoprotein cholesterol lowering and fracture risk : real-world evidence from a target trial emulation study.

Implementation of OMOP and ConcePTION Common Data Models in CPRD GOLD: Risk of Bleeding and Cardiovascular Outcomes From Anticoagulant Use.

The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice.

Checkpoint blockade amplifies pro-regenerative type 2 immunity in tissue repair.

Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing.

Surgery versus non-surgical splint treatment for proximal phalanx shaft finger fractures in adults: the POINT Randomised Controlled Trial.

Cohort Study on Drug Survival and Tolerability of Adalimumab Biosimilar Transitioning: Pharmaceutical Properties Do Matter.

Determinants of six-minute walk test performance in individuals with knee osteoarthritis.

Supervised versus self-managed rehabilitation for patients with an acute first-time or recurrent patellar dislocation: the Physiotherapy Rehabilitation Post Patellar Dislocation (PRePPeD) external pilot randomized controlled trial and embedded qualitative study.

Time to reframe osteoporosis: a position statement to characterize the osteoporosis care gap.

Outcomes in Early Adulthood for Individuals Born Very Preterm and/or with Very Low Birth Weight: Evidence from Multinational Cohorts.

Severe necrotizing soft tissue infections (SENSEI) study: Protocol for a multi-centered audit.

Quantitative Systems Pharmacology Models of Anti-Amyloid Treatments for Alzheimer's Disease: A Systematic Review.

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Find out more about the Kusumbe Group

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