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Concentrations of prostaglandin E2, interleukin-6, and interleukin-8 were determined in the hip joint synovial fluid of 20 patients undergoing primary (n = 12) and revision (n = 8) total hip arthroplasties. Levels of soluble adhesion molecules were also investigated in these patients. There was a significant and marked increase in levels of prostaglandin E2 (P < .001), interleukin-6 (P < .011), interleukin-8 (P < .0002), soluble intercellular adhesion molecule 1 (P < .07), soluble vascular adhesion molecule 1 (P < .0006), and soluble endothelial leukocyte adhesion molecule 1 (P < .0003) in joint fluid of patients undergoing revision. On the basis of these observations, it is suggested that synovial fluid and its inflammatory contents could play a significant role in the pathogenesis of aseptic loosening in total hip arthroplasties.

Original publication

DOI

10.1016/s0883-5403(05)80080-4

Type

Journal article

Journal

The Journal of arthroplasty

Publication Date

12/1995

Volume

10

Pages

810 - 816

Addresses

Orthopaedic Research Unit, University of Cambridge, Addenbrooke's Hospital, United Kingdom.

Keywords

Synovial Fluid, Humans, Osteoarthritis, Hip, Postoperative Complications, Prosthesis Failure, Dinoprostone, Cell Adhesion Molecules, Inflammation Mediators, Interleukin-8, Interleukin-6, Reoperation, Hip Prosthesis, Reference Values, Aged, Aged, 80 and over, Middle Aged, Female, Male