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Human peripheral blood lymphocytes incubated in culture for 1 to 3 days at 37 degree C, but not at 4 degree C, release a soluble factor which can stimulate, up to 400-fold, collagenase production by isolated, adherent, rheumatoid synovial cells. Production of lymphocyte factor is enhanced by phytohemagglutinin or concanavalin A. By gel filtration the factor has an apparent molecular weight of about 12,000.

Original publication

DOI

10.1126/science.188134

Type

Journal article

Journal

Science

Publication Date

14/01/1977

Volume

195

Pages

181 - 183

Keywords

Arthritis, Rheumatoid, Cells, Cultured, Enzyme Induction, Hot Temperature, Humans, Lymphocytes, Lymphokines, Microbial Collagenase, Synovial Membrane