Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development.
Timmis J., Alden K., Andrews P., Clark E., Nellis A., Naylor B., Coles M., Kaye P.
This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose for which it will be applied.