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The antigenic phenotype of human synovial lining cells in normal and hyperplastic synovium intima was determined with a panel of monoclonal antibodies directed against a large number of well defined myeloid (macrophage/granulocyte associated) antigens. Synovial lining cells express numerous macrophage associated antigens, including CD11b (CR3), CD13, CD14, CD16 (FcRIII), CD18, CD32 (FcRII), CD45 (leucocyte common antigen), CD54 (ICAM-1), CD64 (FcRI), CD68, and CD71 (transferrin receptor). Few synovial lining cells expressed CD11a (LFA-1) and CD11c (p150,95). Subintimal macrophages expressed all the macrophage associated antigens which were present on synovial lining cells and, in addition, expressed CD15a, CD25 (interleukin-2 receptor), CD34, and CD35 (C3b receptor), none of which was present on synovial lining cells. Synovial lining cell expression of a wide range of macrophage antigens argues in favour of their marrow origin and membership of the mononuclear phagocyte system.

Original publication

DOI

10.1136/ard.50.5.311

Type

Journal article

Journal

Annals of the rheumatic diseases

Publication Date

05/1991

Volume

50

Pages

311 - 315

Addresses

University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital, Headington.

Keywords

Synovial Membrane, Macrophages, Bone Marrow, Humans, Osteoarthritis, Antigens, CD, Antibodies, Monoclonal, Immunoenzyme Techniques, Cell Differentiation, Aged, Middle Aged, Female, Male