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We report the case of a young female who, from infancy, suffered extensive, progressive, heterotopic ossification of her left lower limb. Heterotopic ossification, which was largely but not exclusively intramembranous in type, was most marked in subcutaneous fat but was also noted in muscle and deep connective tissue. The spectrum of changes noted suggests that this congenital disorder of soft tissues is similar to that recently described as progressive osseous heteroplasia.

Original publication

DOI

10.1016/8756-3282(94)90269-0

Type

Journal article

Journal

Bone

Publication Date

09/1994

Volume

15

Pages

471 - 475

Addresses

Department of Pathology, Nuffield Orthopaedic Centre, Oxford, UK.

Keywords

Abdomen, Hip, Leg, Thigh, Muscle, Skeletal, Bone and Bones, Connective Tissue, Adipose Tissue, Humans, Bone Resorption, Pain, Ossification, Heterotopic, Magnetic Resonance Imaging, Radiography, Amputation, Bone Development, Adolescent, Female