Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

The authors sought the synovial distribution of the interleukin-4 receptor in the synovium of 3 normal subjects, 5 cases of osteoarthritis (OA) and 10 cases of rheumatoid arthritis (RA) and various other inflammatory arthritic conditions. The specific receptor for interleukin-4 was mainly found on cells around subintimal blood vessels and within lymphocytic aggregates where dendritic-like cells were strongly stained. Conversely, synovial lining cells did not express the interleukin-4 receptor. In conclusion, it is believed that the expression of interleukin-4 receptor is restricted to the early activation stage of the mononuclear cells in the pathological joint.


Journal article


Revue du rhumatisme et des maladies osteo-articulaires

Publication Date





219 - 224


University of Oxford, Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, U.K.


Synovial Fluid, Humans, Arthritis, Rheumatoid, Osteoarthritis, Rheumatic Diseases, Receptors, Cell Surface, Interleukin-4, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male