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The authors sought the synovial distribution of the interleukin-4 receptor in the synovium of 3 normal subjects, 5 cases of osteoarthritis (OA) and 10 cases of rheumatoid arthritis (RA) and various other inflammatory arthritic conditions. The specific receptor for interleukin-4 was mainly found on cells around subintimal blood vessels and within lymphocytic aggregates where dendritic-like cells were strongly stained. Conversely, synovial lining cells did not express the interleukin-4 receptor. In conclusion, it is believed that the expression of interleukin-4 receptor is restricted to the early activation stage of the mononuclear cells in the pathological joint.

Type

Journal article

Journal

Revue du rhumatisme et des maladies osteo-articulaires

Publication Date

03/1992

Volume

59

Pages

219 - 224

Addresses

University of Oxford, Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, U.K.

Keywords

Synovial Fluid, Humans, Arthritis, Rheumatoid, Osteoarthritis, Rheumatic Diseases, Receptors, Cell Surface, Interleukin-4, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male