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Most patients with rheumatoid arthritis (RA) exhibit an HLA class II epitope found on most DR4 and DR1 molecules. We have investigated the possibility of other associations being present in the minority of patients lacking these antigens. One hundred and eighty patients with classical or definite RA and 100 controls were assigned HLA-DR, DQ and DP types by a DNA-based system using sequence-specific oligonucleotides to probe amplified class II alleles amplified by the polymerase chain reaction. The expected associations with DR4 (relative risk 10, P less than 0.0001) and DR1 (relative risk 2.3, P less than 0.001) were observed and only 13% of individuals lacked both of these alleles compared with 54% of age- and race-matched controls. A significant association with DRw10 (P = 0.02) was also observed in the DR4/DR1-negative RA group (3/23 patients compared with 0/54 DR4/DR1-negative controls). No novel associations with other DR, DQ, or DP alleles were evident in contrast to some previous studies. The third allelic hypervariable region of the DR beta chain of DRw10 contains a similar amino acid sequence to that found in many DR4 and DR1 molecules. These results extend this correlation and suggest that this susceptibility determinant may account for the HLA-linked susceptibility in 89% of our cases of RA.

Original publication

DOI

10.1093/rheumatology/30.3.178

Type

Journal article

Journal

British journal of rheumatology

Publication Date

06/1991

Volume

30

Pages

178 - 180

Addresses

Molecular Immunology Group, John Radcliffe Hospital, Oxford.

Keywords

Humans, Arthritis, Rheumatoid, Disease Susceptibility, HLA-DR Antigens, HLA-DR1 Antigen, HLA-DR4 Antigen, Amino Acid Sequence, Molecular Sequence Data