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The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

Original publication

DOI

10.1038/ng.2007.32

Type

Journal article

Journal

Nature genetics

Publication Date

12/2007

Volume

39

Pages

1431 - 1433

Addresses

Arthritis Research Campaign (arc)-Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK.

Keywords

Wellcome Trust Case Control Consortium, YEAR Consortium, Chromosomes, Human, Pair 6, Humans, Arthritis, Rheumatoid, Genetic Predisposition to Disease, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome, Human, Female, Male, Protein Tyrosine Phosphatase, Non-Receptor Type 22