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Ankylosing spondylitis is a common inflammatory rheumatic disease. Both susceptibility to and clinical manifestations of the disease are highly heritable. Although some genes, notably HLA-B27, have been implicated in susceptibility to the disease, the genetics of the condition are complex and many more genes involved in the condition await discovery.

Type

Journal article

Journal

Clinical and experimental rheumatology

Publication Date

11/2002

Volume

20

Pages

S43 - S49

Addresses

Wellcome Trust Centre for Human Genetics, Spondyloarthritis and Bone Disease Research Group, Oxford, United Kingdom. mbrown@well.ox.ac.uk

Keywords

Humans, Spondylitis, Ankylosing, HLA-B27 Antigen, HLA-DR Antigens, Severity of Illness Index, Chromosome Mapping, Major Histocompatibility Complex, HLA-DRB1 Chains