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The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This article reviews and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis and reports ongoing initiatives for further development of disease assessment tools. A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and prognosis. The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function.

Type

Journal article

Journal

Annals of the rheumatic diseases

Publication Date

03/2007

Volume

66

Pages

283 - 292

Addresses

Botnar Research Centre, University of Oxford, Oxford, UK.

Keywords

Humans, Vasculitis, Prognosis, Severity of Illness Index, Quality of Life