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The major metabolic pathways involved in synthesis and disposition of carbonyl and hydroxyl group containing compounds are presented, and structural and functional characteristics of the enzyme families involved are discussed. Alcohol and aldehyde dehydrogenases (ADH, ALDH) participate in oxidative pathways, whereas reductive routes are accomplished by members of the aldo-keto reductase (AKR), short-chain dehydrogenases/reductases (SDR) and quinone reductase (QR) superfamilies. A wealth of biochemical, genetic and structural data now establishes these families to constitute important phase I enzymes.

Original publication

DOI

10.1016/s0300-483x(99)00192-4

Type

Journal article

Journal

Toxicology

Publication Date

04/2000

Volume

144

Pages

71 - 81

Addresses

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden. udo.oppermann@mbb.ki.se

Keywords

Animals, Humans, Oxidoreductases, Xenobiotics, Protein Conformation