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Common clinical practice in many tropical paediatric departments is that chloramphenicol courses are limited to 2 weeks due to concerns about anaemia. However, this approach is not supported by current research and animal models. We used chloramphenicol for 6 weeks in 146 children with septic arthritis. All the children improved clinically. Most children were anaemic on presentation (mean haemoglobin [Hb] 8.43 SD 1.9), but the anaemia improved rapidly with clinical resolution of the infection and was maintained at 6 months after presentation (mean Hb 10.57 SD 1.86).

Original publication

DOI

10.1258/004947506776593549

Type

Journal article

Journal

Tropical doctor

Publication Date

04/2006

Volume

36

Pages

114 - 115

Addresses

Department of Orthopaedic surgery, Queen Elizabeth Central Hospital, PO Box 95, Blantyre, Malawi.

Keywords

Humans, Salmonella Infections, Arthritis, Infectious, Anemia, Chloramphenicol, Hemoglobins, Protein Synthesis Inhibitors, Follow-Up Studies, Time Factors, Child, Child, Preschool, Infant, Malawi