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TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's syndrome, systemic lupus erythematosus, and other rheumatic autoimmune diseases. Here, we summarise the structure and function of this enzyme, its roles in innate immunity, adaptive immunity and cellular homeostasis, the pathogenesis of autoimmunity against TRIM21, and the potential impacts of autoantibodies to this intracellular protein.

Original publication

DOI

10.3389/fimmu.2021.738473

Type

Journal article

Journal

Front immunol

Publication Date

2021

Volume

12

Keywords

E3 ubiquitin ligase, Fc receptor, Sjogren’s syndrome, autoimmune disease, innate immunity, intracellular antibodies, systemic lupus erythematosus