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A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immunodeficient mice after transfer of CD45RB(high)CD4(+) T cells. Development of disease can be prevented by cotransfer of the reciprocal CD45RB(low) subset. Analysis of the mechanism of immune suppression transferred by CD45RB(low)CD4(+) cells revealed essential roles for both IL-10 and TGF-beta. These data indicate that a functionally specialized population of regulatory T (Treg) cells exists in normal mice and that these can prevent the development of pathogenic responses toward commensal bacteria. The role of Treg cells in the control of the immune response is discussed.

Original publication

DOI

10.1164/ajrccm.162.supplement_3.15tac9

Type

Journal article

Journal

American journal of respiratory and critical care medicine

Publication Date

10/2000

Volume

162

Pages

S185 - S189

Addresses

Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Keywords

T-Lymphocytes, CD4-Positive T-Lymphocytes, Animals, Humans, Mice, Mice, SCID, Inflammatory Bowel Diseases, Transforming Growth Factor beta, Interleukin-10, Adoptive Transfer