Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.
Ishigaki K., Sakaue S., Terao C., Luo Y., Sonehara K., Yamaguchi K., Amariuta T., Too CL., Laufer VA., Scott IC., Viatte S., Takahashi M., Ohmura K., Murasawa A., Hashimoto M., Ito H., Hammoudeh M., Emadi SA., Masri BK., Halabi H., Badsha H., Uthman IW., Wu X., Lin L., Li T., Plant D., Barton A., Orozco G., Verstappen SMM., Bowes J., MacGregor AJ., Honda S., Koido M., Tomizuka K., Kamatani Y., Tanaka H., Tanaka E., Suzuki A., Maeda Y., Yamamoto K., Miyawaki S., Xie G., Zhang J., Amos CI., Keystone E., Wolbink G., van der Horst-Bruinsma I., Cui J., Liao KP., Carroll RJ., Lee H-S., Bang S-Y., Siminovitch KA., de Vries N., Alfredsson L., Rantapää-Dahlqvist S., Karlson EW., Bae S-C., Kimberly RP., Edberg JC., Mariette X., Huizinga T., Dieudé P., Schneider M., Kerick M., Denny JC., BioBank Japan Project None., Matsuda K., Matsuo K., Mimori T., Matsuda F., Fujio K., Tanaka Y., Kumanogoh A., Traylor M., Lewis CM., Eyre S., Xu H., Saxena R., Arayssi T., Kochi Y., Ikari K., Harigai M., Gregersen PK., Yamamoto K., Louis Bridges S., Padyukov L., Martin J., Klareskog L., Okada Y., Raychaudhuri S.
Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P