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A subset of parvovirus B19 (B19) infected patients retains the infection for years, as defined by detection of B19 DNA in bone marrow. Thus far, analysis of B19-specific humoral immune responses and viral genome variations has not revealed a mechanism for the absent viral clearance. In this study, ex-vivo cellular immune responses were assessed by enzyme linked immunospot assay mounted against the majority of the translated viral genome. Compared to seropositive healthy individuals, individuals with B19 persistence (2-8 years) showed larger number of responses to the structural proteins (P = 0.0022), whereas responses to the non-structural protein were of lower magnitude (P = 0.012). These observations provide the first findings of immunological discrepancies between individuals with B19 persistence and healthy individuals, findings that may reflect both failed immunity and antigenic exhaustion.

Type

Journal article

Journal

Journal of medical virology

Publication Date

01/2006

Volume

78

Pages

129 - 133

Addresses

Institution for Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. adiba.isa@cmm.ki.se

Keywords

Humans, Parvovirus B19, Human, Parvoviridae Infections, Immunoglobulin G, Immunoglobulin M, Viral Nonstructural Proteins, Viral Structural Proteins, Antibodies, Viral, Histocompatibility Testing, Enzyme-Linked Immunosorbent Assay, Adult, Aged, Middle Aged, Female, Male, Interferon-gamma