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A subset of parvovirus B19 (B19) infected patients retains the infection for years, as defined by detection of B19 DNA in bone marrow. Thus far, analysis of B19-specific humoral immune responses and viral genome variations has not revealed a mechanism for the absent viral clearance. In this study, ex-vivo cellular immune responses were assessed by enzyme linked immunospot assay mounted against the majority of the translated viral genome. Compared to seropositive healthy individuals, individuals with B19 persistence (2-8 years) showed larger number of responses to the structural proteins (P = 0.0022), whereas responses to the non-structural protein were of lower magnitude (P = 0.012). These observations provide the first findings of immunological discrepancies between individuals with B19 persistence and healthy individuals, findings that may reflect both failed immunity and antigenic exhaustion.

Original publication

DOI

10.1002/jmv.20514

Type

Journal article

Journal

J Med Virol

Publication Date

01/2006

Volume

78

Pages

129 - 133

Keywords

Adult, Aged, Antibodies, Viral, Enzyme-Linked Immunosorbent Assay, Female, Histocompatibility Testing, Humans, Immunoglobulin G, Immunoglobulin M, Interferon-gamma, Male, Middle Aged, Parvoviridae Infections, Parvovirus B19, Human, Viral Nonstructural Proteins, Viral Structural Proteins