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Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the acute response, was maintained over time, and was also used by a remotely infected individual. Nine CTL clones and two oligoclonal lines obtained from three unrelated individuals used BV5.1, BJ2.1, and a conserved TCR CDR3 of nine amino acids. This commonly recognized epitope is likely important in long-term protective immunity and should be included in vaccine design.

Original publication

DOI

10.1128/jvi.02388-05

Type

Journal article

Journal

Journal of virology

Publication Date

07/2006

Volume

80

Pages

6697 - 6701

Addresses

Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA. vkasprowicz@partners.org

Keywords

CD8-Positive T-Lymphocytes, Humans, Parvovirus B19, Human, Parvoviridae Infections, Complementarity Determining Regions, Viral Vaccines, HLA-A Antigens, Epitopes, T-Lymphocyte, Female, Male, HLA-A24 Antigen