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CD4+ T cells in the mouse can be subdivided into two fractions based on the level of expression of the CD45RB determinant. Previous studies have shown that these subsets are functionally distinct. We have further characterized the properties of these subpopulations in vivo by injecting them into C. B-17 scid mice. The animals restored with the CD45RBhighCD4+ T cell population developed a lethal wasting disease with severe mononuclear cell infiltrates into the colon and elevated levels of IFN-gamma mRNA. In contrast, animals restored with the reciprocal CD45RBlow subset or with unfractionated CD4+ T cells did not develop the wasting or colitis. Importantly, the co-transfer of the CD45RBlow population with the CD45RBhigh population prevented the wasting disease and colitis. These data indicate that important regulatory interactions occur between the CD45RBhigh and CD45RBlowCD4+ T cell subsets and that disruption of this mechanism has fatal consequences.

Original publication

DOI

10.1093/intimm/5.11.1461

Type

Journal article

Journal

International immunology

Publication Date

11/1993

Volume

5

Pages

1461 - 1471

Addresses

DNAX Research Institute of Molecular and Cellular Biology Inc., Palo Alto, CA 94040.

Keywords

CD4-Positive T-Lymphocytes, Animals, Mice, Inbred BALB C, Mice, Mice, SCID, Colitis, Inflammatory Bowel Diseases, Weight Loss, Antigens, CD45, RNA, Messenger, Flow Cytometry, Polymerase Chain Reaction, Female, Interferon-gamma