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Analysing cell migration and invasion is of interest to many investigators as they mimic a part of physiological or pathological events. In this chapter, methods to analyse MMP-dependent 2D and 3D cell migration are described in detail. To study 2D cell migration, the phagokinetic track motility assay can be used. To study 3D cell migration, Matrigel invasion assay or microcarrier beads invasion assay can be used to obtain quantitative results.

Original publication

DOI

10.1007/978-1-60327-299-5_23

Type

Journal article

Journal

Methods in molecular biology (Clifton, N.J.)

Publication Date

01/2010

Volume

622

Pages

379 - 392

Addresses

Imperial College London, Kennedy Institute of Rheumatology, London, UK.

Keywords

Cell Line, Animals, Collagen, Matrix Metalloproteinases, Proteoglycans, Laminin, Drug Combinations, Biological Assay, Microspheres, Cell Movement