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The aetiology of systemic, autoimmune, chronic inflammatory diseases--such as rheumatoid arthritis--is not known, and their pathogenesis is complex and multifactorial. However, progress in the characterization of intercellular mediators--proteins that are now known as cytokines--has led to the realization that one cytokine, tumour-necrosis factor (TNF; previously known as TNF-alpha), has an important role in the pathogenesis of rheumatoid arthritis. This discovery heralded a new era of targeted and highly effective therapeutics for rheumatoid arthritis and, subsequently, other chronic inflammatory diseases.

Original publication

DOI

10.1038/nri802

Type

Journal article

Journal

Nature reviews. Immunology

Publication Date

05/2002

Volume

2

Pages

364 - 371

Addresses

Kennedy Institute, Rheumatology Division, Faculty of Medicine, Imperial College School of Medicine, London, UK. m.feldmann@ic.ac.uk

Keywords

Humans, Arthritis, Rheumatoid, Chronic Disease, Tumor Necrosis Factor-alpha, Antibodies, Monoclonal, Cytokines, History, 20th Century, Female, Male, Clinical Trials as Topic