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Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodelling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. They are multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases (TIMPs). This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology.

Original publication

DOI

10.1016/j.cardiores.2005.12.002

Type

Journal article

Journal

Cardiovascular research

Publication Date

02/2006

Volume

69

Pages

562 - 573

Addresses

Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK. h.nagase@imperial.ac.uk

Keywords

Cardiovascular System, Extracellular Matrix, Animals, Humans, Cardiovascular Diseases, Matrix Metalloproteinases, Tissue Inhibitor of Metalloproteinases, Structure-Activity Relationship, Matrix Metalloproteinase Inhibitors