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New T cell-based blood tests for tuberculosis infection could improve diagnosis of tuberculosis but their clinical utility remains unknown. We describe the role of the ELISpot test in the diagnostic work-up of 13 patients presenting with suspected tuberculosis in routine practice. Of the seven patients with a final diagnosis of active tuberculosis, all were positive by ELISpot including three with false-negative tuberculin skin test results. Rapid determination of tuberculosis infection by ELISpot accelerated the diagnosis of tuberculosis, enabling early treatment initiation.

Original publication

DOI

10.1016/j.jinf.2006.11.002

Type

Journal article

Journal

J infect

Publication Date

03/2007

Volume

54

Pages

e169 - e174

Keywords

Aged, False Negative Reactions, Female, Hematologic Tests, Humans, Immunoassay, Infant, Male, Sensitivity and Specificity, T-Lymphocytes, Tuberculin Test, Tuberculosis