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Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.

Original publication

DOI

10.1128/jvi.79.18.12117-12121.2005

Type

Journal article

Journal

Journal of virology

Publication Date

09/2005

Volume

79

Pages

12117 - 12121

Addresses

Infectious Diseases Unit, Center of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital L08:03, SE-17177 Stockholm, Sweden. oscar.norbeck@cmm.ki.se

Keywords

CD8-Positive T-Lymphocytes, Animals, Humans, Mice, Parvovirus B19, Human, Parvoviridae Infections, Acute Disease, Viral Nonstructural Proteins, Capsid Proteins, Antigens, Viral, Epitopes, Prospective Studies, Amino Acid Sequence, Time Factors, Molecular Sequence Data, Adult, Middle Aged, Female