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Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear.

Original publication

DOI

10.1093/infdis/jis291

Type

Journal article

Journal

The Journal of infectious diseases

Publication Date

06/2012

Volume

205

Pages

1816 - 1820

Addresses

Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford. ruth.simmons@ndm.ox.ac.uk

Keywords

Swiss HIV Cohort Study, Humans, Parvoviridae Infections, Hepatitis C, HIV Infections, Antibodies, Viral, Seroepidemiologic Studies, Female, Male