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Two new methods for preparing phospholipid coated microbubble suspensions are elucidated. Firstly, co-axial electrohydrodynamic atomisation was utilized to generate 3-7 microm diameter microbubbles. Secondly, a specially designed and constructed T-junction device was used to prepare monodisperse microbubbles. Characteristics of microbubbles prepared by these two methods are compared with those obtained by sonication of the phospholipid suspension.

Original publication

DOI

10.1007/s00249-007-0211-x

Type

Journal article

Journal

European biophysics journal : EBJ

Publication Date

04/2008

Volume

37

Pages

515 - 520

Addresses

Department of Mechanical Engineering, University College London, Torrington Place, London, UK.

Keywords

Phospholipids, Contrast Media, Equipment Design, Microbubbles, Biophysics, Electrochemistry, Particle Size, Ultrasonics, Sonication, Optics and Photonics