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Influenza virus immune human T-lymphocyte clones maintained in continuous culture in TCGF were analysed for helper activity and interleukin-2 (IL-2) production. The clones that functioned as helper cells in the production of specific antibody failed to release detectable amounts of IL-2. Conversely, the T cells that produced IL-2 were unable to provide either specific or non-specific helper function. These findings indicated the IL-2 is not an essential component for helper activity. However, phenotypic analysis revealed that both the functional subsets of T-cell clones expressed the helper phenotype in that they were T4+, T3+ and T11+. Nevertheless analysis with other antibodies revealed differences in that the IL-2 releasing clone showed greater staining with the anti-T-cell subset antibodies 9.3 and Leu 8, confirming that there is phenotype as well as functional heterogeneity within the helper inducer T-cell population.

Type

Journal article

Journal

Immunology

Publication Date

11/1983

Volume

50

Pages

397 - 405

Keywords

T-Lymphocytes, T-Lymphocytes, Helper-Inducer, Clone Cells, Humans, Orthomyxoviridae, Interleukin-2, Antibodies, Viral, Antigens, Surface, Epitopes, Lymphocyte Culture Test, Mixed