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The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly-1-2+3+Ia-, although the suppressor effector is Ia+. In both cases a second 'amplifier' cell is required for differentiation of precursors to occur. This cell is found in anti-lymphocyte serum-treated spleen and has the phenotype Ly-1+2+3+Ia-.

Original publication

DOI

10.1084/jem.145.4.793

Type

Journal article

Journal

The Journal of experimental medicine

Publication Date

04/1977

Volume

145

Pages

793 - 801

Keywords

Spleen, T-Lymphocytes, Cell Membrane, Animals, Mice, Immunoglobulin M, Antilymphocyte Serum, Epitopes, Isoantigens, Immunosuppression, Cell Differentiation, Phenotype