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Paget's disease (PD) of the bone is a disorder of bone remodelling that may be polyostotic or monostotic. Although development of a sarcoma in PD is well-recognised, it is less well recognised that pseudosarcomas in bone and soft tissue can also arise in this condition. In this report we document the case of a large giant-cell-rich pseudotumour that developed in the tibia and overlying soft tissues in a case of polyostotic PD. Bone and soft tissues were highly vascular and contained abundant haemorrhage with focal areas of new bone formation and a diffuse infiltrate of osteoclastic giant cells. The lesion has not recurred or produced metastases 3 years after removal. Clinicians should be aware that a benign giant-cell-rich pseudotumour can develop in PD and that it needs to be distinguished from other giant-cell-rich tumours.

Original publication

DOI

10.1007/s00256-012-1558-3

Type

Journal article

Journal

Skeletal radiology

Publication Date

04/2013

Volume

42

Pages

595 - 599

Addresses

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7LD, UK.

Keywords

Leg, Tibia, Giant Cells, Humans, Giant Cell Tumors, Bone Neoplasms, Soft Tissue Neoplasms, Osteitis Deformans, Diagnosis, Differential, Radiography, Treatment Outcome, Follow-Up Studies, Aged, Male