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Paget's disease (PD) of the bone is a disorder of bone remodelling that may be polyostotic or monostotic. Although development of a sarcoma in PD is well-recognised, it is less well recognised that pseudosarcomas in bone and soft tissue can also arise in this condition. In this report we document the case of a large giant-cell-rich pseudotumour that developed in the tibia and overlying soft tissues in a case of polyostotic PD. Bone and soft tissues were highly vascular and contained abundant haemorrhage with focal areas of new bone formation and a diffuse infiltrate of osteoclastic giant cells. The lesion has not recurred or produced metastases 3 years after removal. Clinicians should be aware that a benign giant-cell-rich pseudotumour can develop in PD and that it needs to be distinguished from other giant-cell-rich tumours.

Original publication

DOI

10.1007/s00256-012-1558-3

Type

Journal article

Journal

Skeletal Radiol

Publication Date

04/2013

Volume

42

Pages

595 - 599

Keywords

Aged, Bone Neoplasms, Diagnosis, Differential, Follow-Up Studies, Giant Cell Tumors, Giant Cells, Humans, Leg, Male, Osteitis Deformans, Radiography, Soft Tissue Neoplasms, Tibia, Treatment Outcome