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Advances in wearable sensing and communications infrastructure have allowed the widespread development of prototype medical devices for patient monitoring. However, such devices have not penetrated into clinical practice, primarily due to a lack of research into "intelligent" analysis methods that are sufficiently robust to support large-scale deployment. Existing systems are typically plagued by large false-alarm rates, and an inability to cope with sensor artifact in a principled manner. This paper has two aims: 1) proposal of a novel, patient-personalized system for analysis and inference in the presence of data uncertainty, typically caused by sensor artifact and data incompleteness; 2) demonstration of the method using a large-scale clinical study in which 200 patients have been monitored using the proposed system. This latter provides much-needed evidence that personalized e-health monitoring is feasible within an actual clinical environment, at scale, and that the method is capable of improving patient outcomes via personalized healthcare.

Original publication

DOI

10.1109/tbme.2012.2208459

Type

Journal article

Journal

IEEE transactions on bio-medical engineering

Publication Date

01/2013

Volume

60

Pages

193 - 197

Addresses

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, OX2 6DP, UK. lei.clifton@eng.ox.ac.uk

Keywords

Humans, Monitoring, Ambulatory, Regression Analysis, Normal Distribution, Telemedicine, Clothing, Individualized Medicine