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Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.

Original publication

DOI

10.1146/annurev-biophys-042910-155238

Type

Journal article

Journal

Annual review of biophysics

Publication Date

01/2012

Volume

41

Pages

543 - 556

Addresses

Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, New York, New York 10016, USA. Michael.Dustin@nyumc.org

Keywords

Lymphocytes, Intercellular Junctions, Animals, Humans, Receptors, Immunologic, Cell Communication, Signal Transduction, Immune System Phenomena