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T cell activation depends on extracellular ligation of the T cell receptor (TCR) by peptide-MHC complexes in a synapse between the T cell and an antigen-presenting cell. The process then requires the assembly of signalling complexes between the TCR and the adaptor protein linker for activation of T cells (LAT), and subsequent filamentous actin (F-actin)-dependent TCR cluster formation. Recent progress in each of these areas, made possible by the emergence of new techniques, has forced us to rethink our assumptions and consider some radical new models. These describe the receptor interaction parameters that control T cell responses and the mechanism by which LAT is recruited to the TCR signalling machinery. This is an exciting time in T cell biology, and further innovation in imaging and genomics is likely to lead to a greater understanding of how T cells are activated.

Original publication

DOI

10.1038/nri3066

Type

Journal article

Journal

Nature reviews. Immunology

Publication Date

09/09/2011

Volume

11

Pages

672 - 684

Addresses

Helene and Martin Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10012, USA. michael.dustin@med.nyu.edu

Keywords

Antigen-Presenting Cells, T-Lymphocytes, Animals, Humans, Mice, Actins, Adaptor Proteins, Signal Transducing, Receptors, Antigen, T-Cell, Cytological Techniques, Lymphocyte Activation, Signal Transduction, Immunity, Major Histocompatibility Complex, Immunological Synapses, Molecular Imaging