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Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states.

Original publication

DOI

10.1016/s1359-6101(98)00004-5

Type

Journal article

Journal

Cytokine & growth factor reviews

Publication Date

06/1998

Volume

9

Pages

109 - 116

Addresses

St. Vincent's Institute of Medical Research and The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Vic, Australia. m.gillespie@medicine.unimelb.edu.au

Keywords

T-Lymphocytes, Osteoclasts, Animals, Humans, Neoplasms, Experimental, Diabetes Mellitus, Type 1, Receptors, Interleukin, Interleukin-1, Interleukin-18, Autoimmunity, Gene Expression, Amino Acid Sequence, Molecular Sequence Data, Interleukin-18 Receptor alpha Subunit, Receptors, Interleukin-18