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Monocytic cell lines (HL-60 and THP-1) were infected with viable Mycobacterium leprae. Levels of human hsp60 were estimated by Western blot (immunoblot) assay and a sandwich enzyme-linked immunosorbent assay. The results showed that infection of both of the cell lines induced the synthesis of human hsp60, which may be of significance in relation to autoimmune manifestations associated with mycobacterial infections.

Type

Journal article

Journal

Infection and immunity

Publication Date

10/1996

Volume

64

Pages

4356 - 4358

Addresses

Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

Keywords

Monocytes, Cell Line, Humans, Mycobacterium leprae, Chaperonin 60, Cytokines