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The past few years have witnessed exciting developments regarding the role of cytokines in autoimmune diseases, particularly in rheumatoid arthritis and Crohn's disease, with the demonstration that anti-TNF alpha therapy is clinically beneficial and provides reproducible results. Recent contributions to this field, derived from in vivo studies in animal models of autoimmunity, and increasingly from clinical trials, have greatly enhanced our understanding of this field.

Original publication

DOI

10.1016/s0952-7915(96)80018-5

Type

Journal article

Journal

Current opinion in immunology

Publication Date

12/1996

Volume

8

Pages

872 - 877

Addresses

Kennedy Institute of Rheumatology, Hammersmith, London, UK. f.brennan@s1.cxwms.ac.uk

Keywords

Animals, Humans, Cytokines, Autoimmunity