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OBJECTIVE: Interleukin-10 (IL-10) is a potent inhibitor of the proinflammatory cytokines, including tumor necrosis factor alpha and IL-1, which are considered important in the pathogenesis of rheumatoid arthritis (RA). The study was undertaken to establish whether IL-10 can ameliorate arthritis in the collagen-induced arthritis (CIA) model of RA. METHODS: DBA/1 mice were immunized with bovine type II collagen in adjuvant, and treated daily after disease onset with recombinant murine IL-10 or with saline as a control. Mice were monitored for paw swelling and clinical score. Histologic analysis was also performed. RESULTS: IL-10 treatment of established CIA inhibited paw swelling (P < 0.0001), as well as disease progression as defined by clinical score (P < 0.0002). Cartilage destruction, as assessed histologically, was reduced in IL-10-treated mice compared with controls (P < 0.01). CONCLUSION: IL-10 suppresses established CIA, probably by inhibiting proinflammatory cytokine production. Our results, taken together with previously reported findings, indicate a potential therapeutic role for IL-10 in RA.

Original publication

DOI

10.1002/art.1780390318

Type

Journal article

Journal

Arthritis and rheumatism

Publication Date

03/1996

Volume

39

Pages

495 - 503

Addresses

Kennedy Institute of Rheumatology, London, England.

Keywords

Animals, Mice, Inbred DBA, Cattle, Mice, Arthritis, Experimental, Disease Models, Animal, Collagen, Tumor Necrosis Factor-alpha, Recombinant Proteins, Interleukin-10, Drug Combinations, Dose-Response Relationship, Immunologic, Male