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The nature of the T cell response in the rheumatoid synovium was investigated by using monoclonals MX9 and 42/1C1, which recognize the V beta 8 and V beta 5 T cell receptor gene families respectively. The blood and synovial T cells of ten patients with rheumatoid arthritis were compared. The majority (8/10) had different numbers of V beta 5 and V beta 8 cells in the joints from those in the blood, indicating that the T cells in the joints were not a sample of those in the blood. In three patients both V beta 5 and V beta 8 cells in the joint were augmented in number, suggesting that the T cells selectively retained in the joint were not members of a single clone, but derived from many clones. Some patients had increased levels of V beta 5 or V beta 8 alone in the joint indicating that heterogeneity existed between patients. These results are not consistent with the preferential or dominant use of a single V beta gene family in the T cells involved in the rheumatoid arthritic joints.

Type

Journal article

Journal

Clinical and experimental immunology

Publication Date

09/1988

Volume

73

Pages

417 - 423

Addresses

Immunology Unit, Charing Cross Sunley Research Centre, Switzerland.

Keywords

Synovial Membrane, T-Lymphocytes, Humans, Arthritis, Rheumatoid, Immunoglobulin Variable Region, Receptors, Antigen, T-Cell, Immunoglobulin Idiotypes, Genes, Immunoglobulin