Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Antigen-specific suppressor T cells induced in vitro release, after a further period of culture in vitro with antigen factors into the supernatant which have suppressor activity. These suppressor factors (SF) have the same antigen specificity as the suppressor cells (SC). SF only works on the early phase of thymus-dependent responses in cultures. SF inhibits thymusdependent IgM, but not thymus-independent IgM responses in vitro. SF is is destroyed by proteolytic enzymes, and inactivated at 80 degrees C for 30 min. The release of SF from SC is dependent on the presence of antigen and metabolically active cells.

Original publication

DOI

10.1002/eji.1830070514

Type

Journal article

Journal

European journal of immunology

Publication Date

05/1977

Volume

7

Pages

310 - 314

Keywords

T-Lymphocytes, Cells, Cultured, Animals, Mice, Inbred CBA, Mice, Epitopes, Culture Media, Immunosuppression, Lymphocyte Activation