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The findings we have described here show a clear association between epithelial HLA-D/DR expression and autoimmunity. Furthermore, the ability of class II+ thyrocytes to present both exogenous antigens and autoantigens indicates an active role for these HLA-D/DR molecules in autoimmune pathogenesis. IFN-gamma is capable of inducing HLA-D/DR expression by thyroid epithelium, but a number of observations suggest the involvement of other inducers as well. Overall, we conclude that epithelial class II expression very probably plays a key role in the propagation and also in possibly the initiation of autoimmune attack. This is in accord with the proposal of a more general relationship between inappropriate or excessive class II expression and pathogenesis.

Original publication

DOI

10.1111/j.1749-6632.1986.tb20873.x

Type

Journal article

Journal

Annals of the New York Academy of Sciences

Publication Date

01/1986

Volume

475

Pages

241 - 250

Keywords

Thyroid Gland, Epithelium, Antigen-Presenting Cells, Thyroid Diseases, Autoimmune Diseases, HLA-D Antigens, HLA-DR Antigens, Gene Expression Regulation, Interferon-gamma